Sel-MQC sequences were demonstrated both in phantoms and in vivo, using subcutaneously implanted murine EMT6 tumors. The overall editing efficiency in inhomogeneous fields is increased. The optimized pulses achieve also robust suppression of unwanted signals. Pulses derived from optimal control achieve robust excitation of lactate. Lactate editing by means of selectivepulse filtering of both zero and doublequantum coherence signals. The spatial distribution of lactate can be imaged by the spectroscopic imaging version of Sel-MQC. We optimize a multiple-quantum filter sequence for lactate editing. A selective multi-quantum coherence transfer pulse sequence, SeI-MQC, for detection of lactate (Lac) and total choline (TCho) will be hybridized with a.
The efficiency of lipid suppression is monitored by a 2D Sel-MQC experiment which separates lipid and lactate along the multiple-quantum-evolution dimension. Frequency-selective excitation is employed to selectively prepare lactate into its multiple-quantum states lipid and water are left in the single-quantum modes and eliminated by the multiple-quantum selection gradients. The method is suitable for studying tissues with high fat content and those subject to substantial motion. Sel-MQC sequences were demonstrated both in phantoms and in vivo, using subcutaneously implanted murine EMT6 tumors.ĪB - A novel single-scan selective homonuclear multiple-quantum coherence-transfer technique, Sel-MQC, is presented that achieves lactate editing with complete lipid and water suppression. The spatial distribution of lactate can be imaged by the spectroscopic imaging version of Sel-MQC. The method is suitable for studying tissues with high fat content and those subject to substantial motion. A novel single-scan selective homonuclear multiple-quantum coherence-transfer technique, Sel-MQC, is presented that achieves lactate editing with complete. N2 - A novel single-scan selective homonuclear multiple-quantum coherence-transfer technique, Sel-MQC, is presented that achieves lactate editing with complete lipid and water suppression. T1 - Single-Scan in Vivo Lactate Editing with Complete Lipid and Water Suppression by Selective Multiple-Quantum-Coherence Transfer (Sel-MQC) with Application to Tumors The selective multiple quantum coherence (Sel-MQC) is a useful technique to detect lactate in the environment of lipids.
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